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Biological Actions Similarities of GHK-Copper and Copper Salicylates

GHK has many diverse biological actions, an effect which unfortunately makes acceptance of its biological role by many researchers difficult. However, there is another copper-binding molecule with surprisingly similar actions to GHK-Copper.

The late John R. J. Sorenson (University of Arkansas) developed many salicylate-copper complexes that possess potentially therapeutic actions. The most active of these was diisipropylsalicylate-copper.

Comparison of GHK-copper and copper salicylate actions
Action GHK-copper Diisopropylsalicylate-copper
Wound healing Yes Yes
Inhibit cancer growth Yes Yes
Anti-ulcer Yes Yes
Anti-pain (Analgesic) Yes Yes
Anti-inflammatory Yes Yes
Improve recovery after radiation Yes Yes
Increase stem cells Yes Yes

 

Antiinflammatory, analgesic, and antiulcer activities of copper complexes suggest their use in a physiologic approach to treatment of arthritic diseases. Sorenson JR. Basic Life Sci. 1988;49:591-4. No abstract available

Prog Med Chem. 1989;26:437-568. Copper complexes offer a physiological approach to treatment of chronic diseases. Sorenson JR.

Exp Hematol. 1990 Aug;18(7):801-5. Postirradiation treatment with copper(II)2(3,5-diisopropylsalicylate)4 enhances radiation recovery and hemopoietic regeneration. Soderberg LS1, Barnett JB, Baker ML, Salari H, Sorenson JR.

Radiation protection and radiation recovery with essential metalloelement chelates. Sorenson JR, Soderberg LS, Chang LW. Proc Soc Exp Biol Med. 1995 Dec;210(3):191-204. Review. PMID: 8539256 [PubMed - indexed for MEDLINE]

Exp Hematol. 1988 Aug;16(7):577-80. Copper(II)2(3,5-diisopropylsalicylate)4 stimulates hemopoiesis in normal and irradiated mice. Soderberg LS1, Barnett JB, Baker ML, Chang LW, Salari H, Sorenson JR.

Adv Exp Med Biol. 1989;258:229-34. Bioavailable copper complexes offer a physiologic approach to treatment of chronic diseases. Sorenson JR1, Soderberg LS, Chidambaram MV, de la Rosa DT, Salari H, Bond K, Kearns GL, Gray RA, Epperson CE, Baker ML.

 

CopperTransport_AlbuminDIPS


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