New Data of the Cosmeceutical and TriPeptide GHK
SOFW Journal (2015)
GHK-Cu May Prevent Oxidative Stress in Skin
by Regulating Copper and Modifying Expression of
Numerous Antioxidant Genes Cosmetics (2015)
GHK Peptide as a Natural Modulator of
Multiple Cellular Pathways in Skin Regeneration (2015)
GHK, the Human Skin Remodeling Peptide Induces Anti-Cancer
Expression and DNA Repair Analytical Oncology (2014)
GHK and DNA: Resetting the Human Genome to Health
BioMed Research International (2014)
Avoid Buying Fake Copper Peptides Dangerous

Liver Regeneration

GHK was originally isolated by its actions on increasing the survival of rat liver organ cultures. GHK also increases repair of liver damage in rats.

Rat liver organ culture
GHK-Cu stimulated the survival of normal rat liver cells
Tripeptide in human serum which prolongs survival of normal liver cells and stimulates growth in neoplastic liver, Pickart L, Thaler M, Nature New Biol,1973, 243:85-7
Rats - Effect of GHK on DNA synthesis and immune status Ten intraperitoneal injections of tripeptide Gly-His-Lys in doses of 1.5, 5, 50, 150, and 450 mg/kg stimulated mitotic activity of hepatocytes and dose-dependently suppressed immune reactivity (number of antibody-producing cells and delayed-type hypersensitivity reaction). Smakhtin, MY, Sever’yanova LA, Konoplya AI, Shveinov IA. Tripeptide Gly-His-Lys is a hepatotropic and immunosuppressor. Bull. Exp. Biol. Med. 2002 Jun; 133(6):586-8
Rats- Regeneration of hepatic damage after poison 10-day intraperitoneal administration of Gly-His-Lys in doses 2.5 and 150 mu/kg raises of mitotic index of hepatocytes in acute toxic damage to the liver by dichloromethane (carbon tetrachloride). In the dose 1.5 mu/kg this peptide corrects both functional activity of hepatocytes and immunological responsiveness. In a dose of 150 mu/kg the peptide has a more potent immunosuppressive action and deteriorates biochemical indices of blood serum as well as dystrophic changes in the liver. Smakhtin MI, Konoplia AI, Sever’ianova LA, Sheveinov IA. Pharmacological correction of immuno-metabolic disorders with the peptide Gly-His-Lys in hepatic damage induced by tetrachloromethane. Patol Fiziol Eksp Ter. 2003 Apr-Jun; (2):19-21

KURSKIY SCIENTIFICALLY-PRACTICAL Scientifically-practical journal from Kursk state medical university, Central-Chernozemnogo scientific centre to Russian Academy of the Medical Sciences, Kursk regional branch of the Russian Academy of Natural Sciences, Number 3 – 2006 Year


Reparative activity of different functional group peptides in hepatopathyes. Smakhtin M.Yu., Konoplya A.I., Severyanova L.A., Kurtseva A.A., Cherdakov V.Yu. Biochemistry Department of the Kursk State Medical University

Gly-His-Lys activated hepatocyte reparative regeneration and decreased the immune function in hepatopathies, both with the increased immune function (tetrachloromethane hepatopathy), and with the reduced one (hydrazine hepatopathy). It was the most potent activator of the hepatocyte mitotic activity comparing to an agonist of δ-opiate receptors – peptide DSLET and ACTH4-10. The direction and expression of DSLET and ACTH4-10 effects were not the same in differet toxic hepatopathy models that proved the regulatory influence of these peptides. In comparison to ACTH4-10, DSLET was more potent in activating the reparative liver regeneration and had the immunomodulatory activity.

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