Liver Regeneration
GHK was originally isolated by its actions on increasing the survival of rat liver organ cultures. GHK also increases repair of liver damage in rats.
Rat liver organ culture |
GHK-Cu stimulated the survival of normal rat liver cells |
Tripeptide in human serum which prolongs survival of normal liver cells and stimulates growth in neoplastic liver, Pickart L, Thaler M, Nature New Biol,1973, 243:85-7 |
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| Rats - Effect of GHK on DNA synthesis and immune status | Ten intraperitoneal injections of tripeptide Gly-His-Lys in doses of 1.5, 5, 50, 150, and 450 mg/kg stimulated mitotic activity of hepatocytes and dose-dependently suppressed immune reactivity (number of antibody-producing cells and delayed-type hypersensitivity reaction). | Smakhtin, MY, Sever’yanova LA, Konoplya AI, Shveinov IA. Tripeptide Gly-His-Lys is a hepatotropic and immunosuppressor. Bull. Exp. Biol. Med. 2002 Jun; 133(6):586-8 |
| Rats- Regeneration of hepatic damage after poison | 10-day intraperitoneal administration of Gly-His-Lys in doses 2.5 and 150 mu/kg raises of mitotic index of hepatocytes in acute toxic damage to the liver by dichloromethane (carbon tetrachloride). In the dose 1.5 mu/kg this peptide corrects both functional activity of hepatocytes and immunological responsiveness. In a dose of 150 mu/kg the peptide has a more potent immunosuppressive action and deteriorates biochemical indices of blood serum as well as dystrophic changes in the liver. | Smakhtin MI, Konoplia AI, Sever’ianova LA, Sheveinov IA. Pharmacological correction of immuno-metabolic disorders with the peptide Gly-His-Lys in hepatic damage induced by tetrachloromethane. Patol Fiziol Eksp Ter. 2003 Apr-Jun; (2):19-21 |