Intestinal and Stomach Healing
GHK-Cu has potent effects on the healing of stomach ulcers and intestinal inflammations. One small human study found a very positive effect of GHK-Cu on the healing of intestinal lesions in persons with refractory inflammatory bowel disease.
| Dosage of GHK-Cu | Stomach pH | ||
| none | 2.3 | ||
| 1 milligram | 3.8 | ||
| 3 milligrams | 4.7 | ||
| 10 milligrams | 6.7 |
Likewise, GHK-Cu produced a similar blockage of rat duodenal ulcer formation (cystamine induced).
| Study | Result | Reference |
Healing of stomach and intestinal ulcers |
GHK-Cu was tested for healing of experimental stomach ulcers and intestinal damage in rats. GHK-Cu healed experimental stomach ulcers and intestinal inflammation and damage |
Pickart US Patent 4,767,753 Copper complexes of histidyl-lysine polypeptide(s) for reducing stomach secretions, increasing stomach mucous and preventing ulcers. US Patent 5,023,237 Use of polypeptide or its copper complex for cytoprotection in treatment of intestinal and stomach ulcers, and to facilitate wound healing. US Patent 5,145,838 Methods and compositions for healing ulcers and peptide derivatives. |
Cytoprotective actions against oxygen free radicals |
GHK-Cu markedly inhibited intestinal mucosal tissue from lipid peroxidation by oxygen-derived free radicals |
Alberghina M, Lupo G, La Spina G, Mangiameli A, Gulisano M, Sciotto D, Rizzarelli E, Cytoprotective effect of copper(II) complexes against ethanol-induced damage to rat gastric mucosa, J Inorg Biochem. 1992 Mar;45(4):245-59. |
Human Study - Inflammatory bowel disease |
16 patients with refractory inflammatory bowel disease were treated with rectally administered solutions of GHK-Cu. After the 12 weeks treatment, there was a 60% reduction in severity bas measured by endoscopy, histopathology, and symptoms |
An open study of PC1020 (GHK-Cu) rectal solution in treatment of distal inflammatory bowel disease. Levine, Patt, Koren (University of Washington) World Congress of Dermatology, October 1994; Further details presented at 25th Annual Meeting of DDW, Levine, Patt, Koren, Joslin (University of Washington) May 1995 |