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NEW RELEASE:
Hydrogels for Osteochondral
Tissue Engineering
Journal of Biomedical
Research
(March 2020)		 NEW RELEASE:
Anti-Wrinkle Activity
& Transdermal Delivery
of GHK Peptide
Journal of Peptide Science
(March 2020)
Pulsed Glow Discharge
to GHK-Cu Determination
International Journal
of Mass Spectrometry
(March 2020)		 Protective Effects of GHK-Cu
in Pulmonary Fibrosis
Anti-Inflammation
Life Sciences
(January 2020)
Anti-Wrinkle Benefits
of GHK-Cu Stimulating
Skin Basement Membrane
International Journal of Molecular Sciences
(January 2020)		 Structural Analysis
Molecular Dynamics of
Skin Protective
TriPeptide GHK
Journal of Molecular Structure
(January 2020)
In Vitro / In Vivo Studies
pH-sensitive GHK-Cu in
Superabsorbent Polymer
ACS OMEGA
(2019)		 GHK Enhances
Mesenchymal
Stem Cells Osteogenesis
Acta Biomaterialia
(2019)
Self-Assembled
Antibacterial GHK-Cu
Nanoparticles for
Wound Healing
Particle & Particle (2019)		 Effect of GHK-Cu
on Stem Cells and
Relevant Genes
OBM Geriatrics
(2018)
GHK Alleviates
Neuronal Apoptosis Due
to Brain Hemorrhage
Frontiers in Neuroscience
(2018)		 GHK-Cu:
Endogenous Antioxidant
International Journal of Pathophysiology and Pharmacology (2018)
Regenerative and
Protective Actions of
GHK-Cu Peptide
International Journal of
Molecular Sciences (2018)		 Skin Regenerative and
Anti-Cancer Actions
of Copper Peptides
Cosmetics
(2018)
GHK-Cu Accelerates
Scald Wound Healing
Promoting Angiogenesis
Wound Repair and
Regeneration (2017)
 GHK Peptide Inhibits
Pulmonary Fibrosis
by Suppressing TGF-β1
Frontiers in Pharmacology
 (2017)
UNITED STATES PATENT:
Non-Toxic
Skin Cancer Therapy
with Copper Peptides
(2017)		 The Effect of Human
Peptide GHK Relevant to
Nervous System Function
and Cognitive Decline
Brain Sciences (2017)
Effects of Tripeptide
GHK in Pain-Induced
Aggressive Behavior
Bulletin of Experimental
Biology & Medicine (2017)		 GHK-Cu Elicits
In Vitro Alterations
in Extracellular Matrix
Am Journal of Respiratory
and Critical Care Medicine
(2017)
Selected Biomarkers &
Copper Compounds
Scientific Reports
(2016)		 GHK-Cu on Collagen,
Elastin, and Facial Wrinkles
Journal of Aging Science
(2016)
Tri-Peptide GHK-Cu
and Acute Lung Injury
Oncotarget
(2016)
 Effect of GHK Peptide
on Pain Sensitivity
Experimental Pharmacology
(2015)
New Data of the
Cosmeceutical and
TriPeptide GHK
SOFW Journal
(2015)		 GHK Peptide as a
Natural Modulator of
Multiple Cellular Pathways
in Skin Regeneration
BioMed Research (2015)
Resetting Skin Genome
Back to Health
Naturally with GHK
Textbook of Aging Skin
(2015)		 GHK-Cu May Prevent
Oxidative Stress in Skin
by Regulating Copper and
Modifying Expression of
Numerous Antioxidant Genes Cosmetics (2015)
GHK Increases
TGF-β1 in
Human Fibroblasts
Acta Poloniae
Pharmaceutica
(2014)		 GHK:
The Human Skin Remodeling Peptide Induces Anti-Cancer
Expression and DNA Repair Analytical Oncology
(2014)
GHK & DNA:
Resetting the
Human Genome to Health
BioMed Research
International
(2014)		 Enhanced Tropic Factor Secretion of Mesenchymal
Stem Cells with GHK
Acta Biomater
(2014)
Anxiolytic (Anti-Anxiety)
Effects of GHK Peptide
Bulletin of Experimental
Biology & Medicine
(2014)		 Emphysema-Related
Lung Destruction and
its Reversal by GHK
Genome Medicine
(2012)
TriPeptide GHK Induces
Programmed Cell Death
of Neuroblastoma
Journal of Biotechnology
 (2012)		 Stem Cell
Recovering Effect
of GHK in Skin
Peptide Science
(2012)
Skin Penetration of
Copper Tripeptide in Vitro
Journal of International
Inflammation Research
 (2010)		 Possible Therapeutics
for Colorectal Cancer
Journal of Clinical and
Experimental Metastasis
(2010)
UNITED STATES PATENT:
Methods of Controlling
Differentiation and
Proliferation of Stem Cells
(2005)		 Effects of
Copper Tripeptide
on Irradiated Fibroblasts
American Medical Association (2005)
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Intestinal and Stomach Healing

GHK-Cu has potent effects on the healing of stomach ulcers and intestinal inflammations. One small human study found a very positive effect of GHK-Cu on the healing of intestinal lesions in persons with refractory inflammatory bowel disease.
 

Effects of GHK-Cu on gastric acidity, mucous production and the development of ulcers 
(Shay gastric ulcer model (95% ethanol) in rats)
Dosage of GHK-Cu  Stomach pH
Rats with visible gastric 
Gastric mucous production
none 2.3
72%
Unobservable
1 milligram 3.8
33%
++
3 milligrams 4.7
none
++++
10 milligrams 6.7
none
++++

      Likewise, GHK-Cu produced a similar blockage of rat duodenal ulcer formation (cystamine induced).

Healing of Intestinal and Stomach Ulcers 
Study Result Reference
Healing of stomach and intestinal ulcers 

GHK-Cu was tested for healing of experimental stomach ulcers and intestinal damage in rats.

GHK-Cu healed experimental stomach ulcers and intestinal inflammation and damage
Pickart US Patent 4,767,753   Copper complexes of histidyl-lysine polypeptide(s) for reducing stomach secretions, increasing stomach mucous and preventing ulcers. US Patent 5,023,237   Use of polypeptide or its copper complex for cytoprotection in treatment of intestinal and stomach ulcers, and to facilitate wound healing. US Patent 5,145,838   Methods and compositions for healing ulcers and peptide derivatives.
Cytoprotective actions against oxygen free radicals
GHK-Cu markedly inhibited intestinal mucosal tissue from lipid peroxidation by oxygen-derived free radicals

Alberghina M, Lupo G, La Spina G, Mangiameli A, Gulisano M, Sciotto D, Rizzarelli E, Cytoprotective effect of copper(II) complexes against ethanol-induced damage to rat gastric mucosa, J Inorg Biochem. 1992 Mar;45(4):245-59.
Human Study - Inflammatory bowel disease

16 patients with refractory inflammatory bowel disease were treated with rectally administered solutions of GHK-Cu.

After the 12 weeks treatment, there was a 60% reduction in severity bas measured by endoscopy, histopathology, and symptoms
An open study of PC1020 (GHK-Cu) rectal solution in treatment of distal inflammatory bowel disease.  Levine, Patt, Koren  (University of Washington) World Congress of Dermatology, October 1994;  Further details presented at 25th Annual Meeting of DDW,  Levine, Patt, Koren, Joslin (University of Washington)  May 1995

Questions or Advice?

Email Dr. Loren Pickart: drlorenpickart@gmail.com

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