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NEW RELEASE:
Effect of GHK-Cu
on Stem Cells and
Relevant Genes
OBM Geriatrics (2018)		 GHK-Cu:
Endogenous Antioxidant
International Journal of Pathophysiology and Pharmacology (2018)
Regenerative and Protective
Actions of GHK-Cu Peptide
International Journal of
Molecular Sciences (2018)		 Skin Regenerative and
Anti-Cancer Properties
of Copper Peptides
Cosmetics (2018)
UNITED STATES PATENT:
Non-Toxic
Skin Cancer Therapy
with Copper Peptides (2017)		 The Effect of Human Peptide
GHK Relevant to
Nervous System Function
and Cognitive Decline
Brain Sciences (2017)
Tri-Peptide GHK-Cu
and Acute Lung Injury
Oncotarget
(2016)		 New Data of the
Cosmeceutical
and TriPeptide GHK
SOFW Journal (2015)
GHK Peptide as a
Natural Modulator of
Multiple Cellular Pathways
in Skin Regeneration (2015)		 GHK-Cu May Prevent
Oxidative Stress in Skin
by Regulating Copper and
Modifying Expression of
Numerous Antioxidant Genes Cosmetics (2015)
GHK:
The Human Skin Remodeling Peptide Induces Anti-Cancer
Expression and DNA Repair Analytical Oncology (2014)		 GHK & DNA: Resetting the
Human Genome to Health
BioMed Research International (2014)
Emphysema-Related
Lung Destruction and
its Reversal by GHK
Genome Medicine (2012)		 TriPeptide GHK Induces
Programmed Cell Death
of Neuroblastoma
Journal of Biotechnology
 (2012)
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Intestinal and Stomach Healing

GHK-Cu has potent effects on the healing of stomach ulcers and intestinal inflammations. One small human study found a very positive effect of GHK-Cu on the healing of intestinal lesions in persons with refractory inflammatory bowel disease.
 

Effects of GHK-Cu on gastric acidity, mucous production and the development of ulcers 
(Shay gastric ulcer model (95% ethanol) in rats)
Dosage of GHK-Cu  Stomach pH
Rats with visible gastric 
Gastric mucous production
none 2.3
72%
Unobservable
1 milligram 3.8
33%
++
3 milligrams 4.7
none
++++
10 milligrams 6.7
none
++++

      Likewise, GHK-Cu produced a similar blockage of rat duodenal ulcer formation (cystamine induced).

Healing of Intestinal and Stomach Ulcers 
Study Result Reference
Healing of stomach and intestinal ulcers 

GHK-Cu was tested for healing of experimental stomach ulcers and intestinal damage in rats.

GHK-Cu healed experimental stomach ulcers and intestinal inflammation and damage
Pickart US Patent 4,767,753   Copper complexes of histidyl-lysine polypeptide(s) for reducing stomach secretions, increasing stomach mucous and preventing ulcers. US Patent 5,023,237   Use of polypeptide or its copper complex for cytoprotection in treatment of intestinal and stomach ulcers, and to facilitate wound healing. US Patent 5,145,838   Methods and compositions for healing ulcers and peptide derivatives.
Cytoprotective actions against oxygen free radicals
GHK-Cu markedly inhibited intestinal mucosal tissue from lipid peroxidation by oxygen-derived free radicals

Alberghina M, Lupo G, La Spina G, Mangiameli A, Gulisano M, Sciotto D, Rizzarelli E, Cytoprotective effect of copper(II) complexes against ethanol-induced damage to rat gastric mucosa, J Inorg Biochem. 1992 Mar;45(4):245-59.
Human Study - Inflammatory bowel disease

16 patients with refractory inflammatory bowel disease were treated with rectally administered solutions of GHK-Cu.

After the 12 weeks treatment, there was a 60% reduction in severity bas measured by endoscopy, histopathology, and symptoms
An open study of PC1020 (GHK-Cu) rectal solution in treatment of distal inflammatory bowel disease.  Levine, Patt, Koren  (University of Washington) World Congress of Dermatology, October 1994;  Further details presented at 25th Annual Meeting of DDW,  Levine, Patt, Koren, Joslin (University of Washington)  May 1995

Questions or Advice?

Email Dr. Loren Pickart: drlorenpickart@gmail.com

Alternate Email: ghkcopperpeptides@gmail.com

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