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NEW RELEASE:
GHK Enhances
Mesenchymal Stem Cells
Osteogenesis
Acta Biomaterialia (2019)
Self-Assembled
Antibacterial GHK-Cu
Nanoparticles for
Wound Healing
Particle & Particle (2019)
Effect of GHK-Cu
on Stem Cells and
Relevant Genes
OBM Geriatrics
(2018)
GHK Alleviates
Neuronal Apoptosis Due
to Brain Hemorrhage
Frontiers in Neuroscience
(2018)
GHK-Cu:
Endogenous Antioxidant
International Journal of Pathophysiology and Pharmacology (2018)
Regenerative and
Protective Actions of
GHK-Cu Peptide
International Journal of
Molecular Sciences
(2018)
Skin Regenerative and
Anti-Cancer Actions
of Copper Peptides
Cosmetics
(2018)
GHK-Cu Accelerates
Scald Wound Healing
Promoting Angiogenesis
Wound Repair and
Regeneration
(2017)

GHK Peptide Inhibits
Pulmonary Fibrosis
by Suppressing TGF-β1
Frontiers in Pharmacology
(2017)
UNITED STATES PATENT:
Non-Toxic
Skin Cancer Therapy
with Copper Peptides
(2017)
The Effect of Human
Peptide GHK Relevant to
Nervous System Function
and Cognitive Decline
Brain Sciences (2017)
Effects of Tripeptide
GHK in Pain-Induced
Aggressive Behavior
Bulletin of Experimental
Biology & Medicine
(2017)
GHK-Cu Elicits
In Vitro Alterations
in Extracellular Matrix
Am Journal of Respiratory
and Critical Care Medicine

(2017)
Selected Biomarkers &
Copper Compounds
Scientific Reports

(2016)
GHK-Cu on Collagen,
Elastin, and Facial Wrinkles
Journal of Aging Science
(2016)
Tri-Peptide GHK-Cu
and Acute Lung Injury
Oncotarget
(2016)

Effect of GHK Peptide
on Pain Sensitivity
Experimental
Pharmacology
(2015)

New Data of the
Cosmeceutical
and TriPeptide GHK
SOFW Journal
(2015)
GHK Peptide as a
Natural Modulator of
Multiple Cellular Pathways
in Skin Regeneration
BioMed Research (2015)
Resetting Skin Genome
Back to Health
Naturally with GHK
Textbook of Aging Skin
(2015)
GHK-Cu May Prevent
Oxidative Stress in Skin
by Regulating Copper and
Modifying Expression of
Numerous Antioxidant Genes Cosmetics (2015)
GHK Increases
TGF-β1 in
Human Fibroblasts

Acta Poloniae
Pharmaceutica

(2014)
GHK:
The Human Skin Remodeling Peptide Induces Anti-Cancer
Expression and DNA Repair Analytical Oncology
(2014)
GHK & DNA:
Resetting the
Human Genome to Health
BioMed Research
International
(2014)
Enhanced Tropic Factor Secretion of Mesenchymal
Stem Cells with GHK
Acta Biomater
(2014)
Anxiolytic (Anti-Anxiety)
Effects of GHK Peptide
Bulletin of Experimental
Biology & Medicine
(2014)
Emphysema-Related
Lung Destruction and
its Reversal by GHK
Genome Medicine
(2012)
TriPeptide GHK Induces
Programmed Cell Death
of Neuroblastoma
Journal of Biotechnology
(2012)
Stem Cell
Recovering Effect
of GHK in Skin
Peptide Science
(2012)
Skin Penetration of
Copper Tripeptide in Vitro
Journal of International
Inflammation Research
(2010)
Possible Therapeutics
for Colorectal Cancer
Journal of Clinical and
Experimental Metastasis
(2010)
UNITED STATES PATENT:
Methods of Controlling
Differentiation and
Proliferation of Stem Cells
(2005)
Effects of
Copper Tripeptide
on Irradiated Fibroblasts
American Medical Association
(2005)
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Stimulation of Fingernail Growth

During prolonged rainy periods in Washington State, horses often develop severe irritations in their lower extremities – especially where the hair covered skin joins to the hooves. This skin area can develop irritations, infections and bleeding. During experiments to heal such irritated skin with creams containing copper peptides, the application of the copper-peptide cream was often imprecise due to movements of the horses and the cream were generously applied to the lower skin of the leg and part of the upper hooves. While the creams were observed to rapidly heal the skin areas, we also unexpectedly observed that damaged hooves appeared to improve markedly in health. Later, we experimented with more controlled application of the copper peptide creams into cracks in badly damaged hooves. We found that the copper peptide cream usually produced a remarkable healing of the hooves and closure of the cracks.       

Since the hooves of horses and the nails of humans are similar in terms of their biochemistry and cellular biology, we tested the application of such copper peptide creams to damaged human fingernails and toenails. We observed that such treatment produced in humans, as in the horses, a remarkable improvement in nail health and growth. Such types of copper-peptides, when applied to the nail matrix and nail bed area, enhance the process of nail growth resulting in stronger, thicker and smoother nails. Such types of copper-peptides have previously been found to strongly enhance the production of the protein collagen and also accelerate the repair of damaged skin. However, since nails are primarily composed of the hard protein keratin, it was not expected that copper-peptides would increase the production of keratin and nail growth.       

We then studied the actions of a copper-peptide cream in an informal pilot study on nail growth in humans. The Placebo Control nails were treated with a similar cream that contained no copper-peptide. For testing experiments, the fingernail growth rates of the index finger were used as a measurement. In the first set of experiments, the cream was applied to the index fingernail and cuticle on the right hand while the left hand nail was untreated and used as a control. In the second set of experiments with different volunteers, the cream was applied to the index fingernail and cuticle on the left hand while the right hand nail was treated with the placebo cream and used as a control. Nails were treated for four weeks. Nail length was measured from the end of the nail bed to the tip of the nail at its center by pushing a small plastic ruler under the nail and firmly against the nail bed. The nails were also visually inspected to determine that the treated nails appeared to be longer on the treated hand and this was readily apparent in all cases. The effect of nail growth stimulation was approximately similar if either the right hand treated group or the left hand treated group was used. As seen in Table 1, Nails treated with the copper-peptide complex had better nail growth. However, it must be emphasized this was not a blinded study.
 

Table 1 - Effect of Copper Peptides on Nail Growth
First Experiment (Sex)
Finger Nail Growth with Copper Peptide Cream
(Millimeters in four weeks)
Finger Nail Growth with Placebo cream 
(Millimeters in four weeks)
Right Hand
Left Hand
Person 1M
4.2
2.7
Person 2M
3.2
2.1
Person 3F
4.3
3.2
Person 4F
3.8
2.9
Person 5F
3.9
2.6
 
Second Experiment 
Left Hand
Right Hand
Person 6M
2.8
1.5
Person 7M
3.7
2.6
Person 8F
4.1
3.0
Person 9F
4.1
2.6
Person 10F
3.5
2.2

Questions or Advice?

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