Bone Healing
| Study | Result | Reference |
|---|---|---|
Bone Healing GHK-Cu was tested for healing of bone tissue |
GHK-Cu markedly stimulated bone repair |
Pickart L, US Patent 5,059,588 New and known copper peptide complexes for bone healing containing glycyl-histidyl-lysine and lysyl-histidyl-glycine. |
| Functions of bone forming cells. Effect of GHK-Cu on bone forming cells | GHK-Cu increases the number of human marrow stromal cells and promotes the attachment of human osteoblastic cells. | Effects of the tripeptide glycyl-L-histidyl-L-lysine copper complex on osteoblastic cell spreading, attachment and phenotype. Godet and Marie (INSERM, Cell and Molecular Biology of Bone and Cartilage, Lariboisiere Hospital, Paris, France) Cell Mol Biol (Noisy-le-grand) 1995 41(8):1081-91 |
Chick Bone forming cells Growth of bone chondrocytes |
GHK-CU increased chondrocyte growth and their synthetic rate of bone collagen. Authors suggests GHK-Cu may be useful in the preparation of cartilage implants. | Effect of the tripeptide glycyl-L-histidyl-L-lysine on the proliferation and synthetic activity of chick embryo chondrocytes. Pesakova, Novotna, and Adam (Institute of Rheumatology, Postgraduate Medical School, Czech Republic) Biomaterials 1995 16(12):911-5 |
Bone Healing The effect of GHK-Cu on the stimulation of new bone production in guinea pigs was studied.The authors prepared 7.5% and 12.5% collagen gels, supplemented with the tripeptide GHK-Cu, perfloxacine and hypersulphated glycosaminoglycan (HSGAG). |
The gels were tested in guinea pigs for filling artificially created bone defects in diaphyses of femurs, and with cementless endoprostheses. Bone healing process was followed by means of RTG and NMR, and histologically. The slowest healing process was found in unfilled bone defects. Defects filled with Colladel without GHK-Cu healed more quickly, and the most accelerated healing was with the gels with GHK-Cu. The optimum gel, when used with cementless endoprostheses, produced vivid osteogenic activity at the interface of trabecular bone and metal stem. | Morphological features of bone healing under the effect of collagen-graft-glycosaminoglycan copolymer supplemented with the tripeptide Gly-His-Lys. Pohunkova, Stehlik, Vachal, Cech and Adam Institute of Rheumatology, Charles University, Prague, Czech Republic. Biomaterials 1996, 17(16):1567-74 |
GHK-Cu stimulates bone healing in animals and the functions of bone repair cells in culture. The development of GHK-Cu for clinical use is being conducted under the direction of Prof. Milan Adam (University of Prague, Photograph - on the left) . Adam developed a collagen-graft-glycosaminoglycan copolymer supplemented with GHK-Cu for bone healing.