The Effect of Human Peptide GHK Relevant to
Nervous System Function and Cognitive Decline
Brain Sciences (2017)
New Data of the Cosmeceutical and TriPeptide GHK
SOFW Journal (2015)
GHK-Cu May Prevent Oxidative Stress in Skin
by Regulating Copper and Modifying Expression of
Numerous Antioxidant Genes Cosmetics (2015)
GHK Peptide as a Natural Modulator of
Multiple Cellular Pathways in Skin Regeneration (2015)
GHK, the Human Skin Remodeling Peptide Induces Anti-Cancer
Expression and DNA Repair Analytical Oncology (2014)
GHK and DNA: Resetting the Human Genome to Health
BioMed Research International (2014)
Avoid Buying Fake Copper Peptides Dangerous







Cosmetic Skin Renewal and Aging Reversal Studies

 
Study Result References
Methods to Reverse Aging Effects in
Human Skin
Several open studies gave evidence for wrinkle reduction, blemish reduction, increased skin thickness, elasticity, and improved appearance. Pickart  US Patents, 5,135,913   Skin treatment composition comprises GHL-CU or derivatives for improving skin health, increasing subcutaneous fat, dermal thickness and density, 5,348,943   Cosmetic and skin treatment compositions.
Human Skin Renewal Study

A clinical study which compared the effect on the skin's production of collagen after using creams containing copper-peptides, vitamin C, or retinoic acid (retin-A) Twenty volunteers applied the various creams to their thighs daily for one month. New collagen production was determined by studying skin biopsy samples using immunohistological techniques.

The study found, that after one month, copper-peptides had the most significant effect on collagen production. Significant increases in collagen production were found in 70% of the persons treated with copper-peptide creams, 50% of the persons treated with the vitamin C cream, and 40% of the persons treated with retinoic acid. The results are awesome!
Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin - A pilot clinical, histologic, and ultrastructural study. Abdulghani A.A.; Sherr A.; Shirin S.; Solodkina G.; Tapia E.M.; Wolf.GottliebA.B.; Dermatology, UMDNJ, Robert Wood Johnson Medical School; Disease Management and Clinical Outcomes, 1998, 1:136-141.
Human Skin Renewal Study
GHK-Cu containing liquid foundation tested on skin appearance, skin elasticity and epidermal thickness in an 8 week study. GHK-Cu containing liquid foundation improved skin appearance, and increased skin elasticity and epidermal thickness.

A Clinical Evaluation of a Copper-Peptide Containing Liquid Foundation and Cream Concealer Designed for Improving Skin Condition.  Appa Y, Barkovic S, Finkey M B, Neutrogena Corporation, Los Angeles, CA,  Stephens, T, TJ Stephens & Associates, Inc, Dallas, TX Abstract P66, American Academy of Dermatology Meeting,  February 2002

Reduction of Photo Damage
GHK-Cu containing creams tested for reducing visible signs of aging and increasing skin density. GHK-Cu containing creams reduced visible signs of aging and increased skin density in 8 weeks on facial skin. 

The Effect of Tripeptide to Copper Ratio in Two Copper Peptide Creams on Photoaged Facial Skin. Leyden J, University of Pennsylvania, Philadelphia, PA,  Grove,  G, KGL, Inc/Skin Study Center, Broomall, PA;  Barkovic S, Appa Y, Neutrogena Corporation, Los Angeles, CA; Abstract P67, American Academy of Dermatology Meeting, February 2002
Human Skin Renewal Study
GHK-Cu containing creams tested for effect on wrinkles, fine line, skin elasticity, skin density, and thickness. Placebo-controlled study, 71 females, 12 weeks. GHK-Cu containing creams reduced wrinkles and fine lines while increasing skin elasticity, skin density, and thickness.  Skin Care Benefits of Copper Peptide Containing Facial Cream. Leyden J, University of Pennsylvania, Philadelphia, PA  Stephens T, Thomas J Stephens & Associates, Inc, Dallas, TX; Finkey MB, Barkovic S, Neutrogena Corporation, Los Angeles, CA; Abstract P68, American Academy of Dermatology Meeting,  February 2002
Human Skin Renewal Study
GHK-Cu containing eye creams tested on wrinkles, fine lines and eye appearance in placebo controlled study, 41 females, 12 weeks. In a second placebo controlled, 3 week, half face study, GHK-Cu was significantly better than a vitamin K cream.

GHK-Cu containing eye creams reduced wrinkles and fine lines while improving eye appearance in placebo-controlled study. 

GHK-Cu was significantly better than a vitamin K cream.

Skin Care Benefits of Copper Peptide Containing Eye Creams.  Leyden J, University of Pennsylvania, Philadelphia, PA; Stephens T, Thomas J Stephens & Associates, Inc, Dallas, TX; Finkey MB, Barkovic S, Neutrogena Corporation, Los Angeles, CA; Abstract P69, American Academy of Dermatology Meeting, February 2002
Review
Review of skin remodeling Pickart L, Copper Peptides for Tissue Regeneration, Specialty Chemicals, Oct. 9, 2002, 29-31. 2002
Human Skin Renewal Study
Renewal with GHK-Cu in SPF 20 skin cream Stephens TJ, Sigler ML, Finkley MB, Appa Y, Skin benefits of a SPF-20 copper peptide containing skin cream, 61th Amer Acad Derm Meeting, San Francisco, 2003
Review
Review of skin remodeling Pickart L, Copper peptides for aging reversal, Body Language Dermatology, April 2003,
Review
Review of skin remodeling Pickart, L, Copperceuticals and the skin, Cosmetics & Toiletries 2003, 118:24-28
Theory of Skin Remodeling
Biochemical theory of mechanism of skin remodeling Pickart L, Skin remodeling copper peptides, Cosmetics & Medicine (Russia) 2004, Number 2, pages 14-29,
Review of Cosmetic Studies on GHK-Cu

A series of placebo-controlled studies found GHK-Cu skin creams to:
1. Tighten loose skin and improve elasticity
2. Improve skin density and firmness
3. Reduce fine lines and deep wrinkles 4. Improve skin clarity
5. Reduce photodamage and mottled hyperpigmentation
6. Strongly increase keratinocyte proliferation in women of 50 year old range

Copper Peptide and Skin, M.B. Finkley, Y. Appa, S. Bhandarkar, Cosmeceuticals and Active Cosmetic, 2nd Edition (ISBN: 0-8247-4239-7), 2005, pp 549-563
GHK actions on sebum production
GHK suppresses sebum production in cultured sebocytes but not overall lipid synthesis Schagen S, Voegeli R, Imfeld D, Schreier T, Zouboulis CC, Lipid regulation in SZ95 sebocytes by glycyl-histidyl-lysine, 16th European Academy of Dermatology and Venereology Congress, 16-20 May 2007
Review of Remodeling
Review of the New Biochemistry and Cell Biology of Skin Remodeling Pickart L, The human tripeptide GHK and tissue remodeling, "Wound Healing and Technology", J. Biomater, Sci. Polymer Edit. Vol 19, No. 8 pp. 969-988 (2008).
Skin Penetration of Copper Peptides
GHK-Cu penetrates skin via the horny lipid layer of the skin barrier

Mazurowska L, Mojski M, Biological activities of selected peptides: skin penetration ability of copper complexes with peptides, J Cosmet Sci. 2008 Jan-Feb;59(1):59-69.

Update on Remodeling
Presented at Wound Healing Society, April 2008

Pickart L and Pickart F, GHK defines the biochemical reactions of tissue remodeling.

Look at http://www.skinbiology.com/copperpeptideregeneration-WHS2008.html

Questions or Advice?

Email Dr. Loren Pickart at drlorenpickart@gmail.com

Alternate Email: Ghkcopperpeptides@gmail.com

Call us at 1-800-405-1912 Monday through Friday (8 am to 6 pm) PST